Journal of Pharmaceutical Sciences p. 1175 - 1177 (1984)
Update date:2022-07-31
Topics:
Andreani
Bonazzi
Rambaldi
Galatulas
Bossa
The synthesis of two nitrogen mustard derivatives (VIII and IX) related to the well-known local anesthetic ketocaine (III) is reported. These compounds were tested in mice implanted with Ehrlich ascites tumor cells, and the antitumor activity was compared with that of two previously synthesized analogues (I and II) lacking the nitro group and with that of doxorubicin. The monofunctional compound IX was inactive, but the bifunctional compound VIII showed potent antitumor activity (%T/C > 254 at 20 mg/kg).
View MoreShanghai Potomer International Trade CO., LTD
Contact:+86-21-61397128
Address:Room 304,No.505 ,Caoyang Road.Shanghai,China
Contact:86-571-86737118-8689
Address:No.69, 12 Street, HEDA, Hangzhou, Zhejiang, China
Beijing Tianjia Chemical Science & Technology Co.,Ltd
Contact:86-0550-2392698
Address:No.388, Shiliang Road (East),
Anhui New Star Pharmaceutical Development Co., Ltd
Contact:013956922763
Address:Floor 3, F9A, F Workshop, No.110 Kexue Road, High-Tech Development Zone, Hefei, Anhui ,China
Synchem Pharma Co.,Ltd(expird)
Contact:+0086-21-61984905-1
Address:Building 60,Zimian Park, LongYang industrial Area, 1515Nong,Yuandong Road Fengxian District, Shanghai ,China
Doi:10.1039/c5sc03854e
(2016)Doi:10.1055/s-2006-950293
(2006)Doi:10.1039/d1sc01351c
(2021)Doi:10.1016/S0040-4039(01)81349-6
(1984)Doi:10.1039/c1jm10667h
(2011)Doi:10.1021/jm00331a007
(1964)