Journal of Agricultural and Food Chemistry p. 1044 - 1051 (1995)
Update date:2022-08-04
Topics:
Bargar, Thomas M.
Lett, Renee M.
Johnson, Peter L.
Hunter, James E.
Chang, C. P.
et al.
A series of 13 simplified analogs of frog skin derived pumiliotoxin indolizidine alkaloids was prepared and evaluated for their toxicity to the larvae of the important cotton pest Heliothis virescens.The alkyl side chain of pumiliotoxin 251D was replaced with a variety of substituents designed to influence or restrict its conformation and its ability to act as a site of metabolic detoxification.Significantly, a substituent in the R configuration at the C-2' carbon of the side chain was required for toxicity.Computational studies suggested that this substituent may control the active conformation of the side chain.No structural modification led to a significant improvement in toxicity over the natural product.Keywords: Pumiliotoxin; insecticide; Heliothis virescens; structure-activity
View MoreContact:86-25-51817806
Address:No. 216, middle longpan road, jincheng tower, floor 21-22, nanjing ,china
website:http://www.oceanchem-group.com
Contact:86-536-8596048
Address:9th floor,Building B future Plaza, No.88.Fenghuang Street,Weifang,Shandong,China
website:http://www.herbpurify.com
Contact:0086-028-85249238
Address:Room709-C1,Incubator Building, Tianfu Life Science Park No.88,Keyuan Road,Gaoxin district,Chengdu City,Sichuan Prov,China
FREEBARQUE DEVELOPMENT GROUP LIMITED
Contact:+86(0)10-5109 5335 or 5109 5345
Address:Room602,Block1-B,LINGDI OFFICE,NO.13 BEIYUAN ROAD
Contact:+86-533-3112891
Address:zibo
Doi:10.1055/s-0030-1261204
(2011)Doi:10.1021/ja00222a065
(1988)Doi:10.1039/b510776h
(2005)Doi:10.1055/s-1984-30832
(1984)Doi:10.1039/P29840001259
(1984)Doi:10.1007/BF00506963
(1984)