SYNTHESIS OF 5-HYDROXY- AND 5-ACYLHYDRAZINOPYRAZOLIDINES BY THE REACTION OF &β-SUBSTITUTED HYDRAZIDES WITH &α,&β-UNSATURATED ALDEHYDES AND THEIR BIOLOGICAL ACTIVITY

Article abstract of DOI:10.1007/BF00514307

The reaction of β-substituted hydrazides with alkenals (acrolein, methacrolein, crotonaldehyde, and cinnamaldehyde) serves as a method for the synthesis of the corresponding 1-acyl-5-hydroxypyrazolidines and, in a number of cases, 1-acyl-5-acylhydrazinopyrazolidines.Some of the 1-acyl-5-hydroxypyrazolidines obtained have antiphlogistic activity.