Direct Enantiomeric Resolution of Some 7,12-Dimethylbenzanthracene Derivatives by High-Performance Liquid Chromatography with Ionically and Covalently bonded Chiral Stationary Phases

Article abstract of DOI:10.1021/ac00278a009

The direct resolution of the enantiomers of trans-3,4-dihydrodiol, trans-5,6-dihydrodiol, cis-5,6-dihydrodiol, trans-8,9-dihydrodiol, and 8,9,10,11-tetrahydro-trans-8,9-diol of 7,12-dimethylbenzanthracene was evaluated by high-pepformance liquid chromatography using commercially available columns packed with (R)-N-(3,5-dinitrobenzoyl)phenylglycine and (S)-N-(3,5-dinitrobenzoyl)leucine either ionically or covalently bonded to γ-aminopropylsilanized silica.The enantiomers of all diol derivatives were resolved by one or more, but not all, of the chiral stationary phases tested.Resolution of enentiomers was confirmed by ultraviolet-visible absorption, mass, and circular dichroism spectral analyses.