Synthesis and Stereochemistry of 2,5-Dimethoxy 3,6-Disubstituted 1,4-Dioxanes Obtained from α-Hydroxy Dimethyl Acetals

Article abstract of DOI:10.1021/jo00198a002

Several α-hydroxy dimethyl acetals were shown to undergo bimolecular loss of CH3OH under acid catalysis to yield the corresponding 1,4-dioxane.In the case of the 3,3-dimethoxy-2-pentanol (5) rearrangement accounts for the formation of 3,6-diethyl-2,5-dime