A NOVEL ROUTE TO 5-FLUOROURACILS FROM CHLOROTRIFLUOROETHENE

DOI: 10.1246/cl.1984.1573

Source and publish data:

Chemistry Letters p. 1573 - 1576 (1984)

Update date:2022-09-26

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Authors:

Fuchikami, Takamasa

Yamanouchi, Akiko

Suzuki, Yasuyuki

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Article abstract of DOI:10.1246/cl.1984.1573

Diethyl fluoromalonate was prepared in one-pot from chlorotrifluoroethene via trifluoroacrylic acid lithium salt in 79percent yield.Diethyl fluoromalonate was easily converted to 5-fluoro-6-chlorouracils, reductions of which gave 5-fluorouracils in good yields.

Full text of DOI:10.1246/cl.1984.1573

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