Synthesis of acyclic α,β-unsaturated ketones via Pd(II)-catalyzed intermolecular reaction of alkynamides and alkenes

Article abstract of DOI:10.1021/ja068886f

We report an intermolecular oxidative coupling of alkynamides and terminal alkenes to synthesize E-α,β-unsaturated ketones under very mild conditions using catalytic Pd(II) and an oxidant. An ¹⁷O isotope labeling experiment implicates a cyclic