Bioorganic and Medicinal Chemistry Letters p. 3130 - 3135 (2007)
Update date:2022-08-03
Topics: Synthesis Lipophilicity In vitro Selectivity Mass spectrometry (MS) Enantiomers HPLC (high-performance liquid chromatography) NMR (nuclear magnetic resonance) in vivo Biological Evaluation Structure-Activity Relationship (SAR) Pharmacokinetics Dose-Response Curve Diamine Receptor binding assay IC50 SAR optimization
Stocking, Emily M.
Miller, Jennifer M.
Barbier, Ann J.
Wilson, Sandy J.
Boggs, Jamin D.
McAllister, Heather M.
Wu, Jiejun
Lovenberg, Timothy W.
Carruthers, Nicholas I.
Wolin, Ronald L.
The synthesis and structure-activity relationships of a series of novel phenoxyphenyl diamine derivatives with affinity for both the histamine H3 receptor and the serotonin transporter is described.
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Doi:10.1016/S0031-9422(00)80539-7
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(2007)