Synthesis, cytotoxicity assessment, and molecular docking of 4-substituted-2-p-tolylthiazole derivatives as probable c-Src and erb tyrosine kinase inhibitors

Article abstract of DOI:10.5562/cca1939

In the current project we focused on the synthesis of 4-Substituted-2-p- tolylthiazole derivatives. Cytotoxicity of synthesized compounds were evaluated against T47D breast cancer cell line and also all of the final compounds 3-7 were docked into the active site of c-Src and erb tyrosine kinases. Compound 4 was the most potent derivative in cytotoxicity assay (IC50 = 2.5 μg/mL) and it was also the most potent inhibitor of erb tyrosine kinase (Binding free energy: -10.18 kcal/mol).

Full text of DOI:10.5562/cca1939

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