Synthesis of fluorinated acyclic nucleoside phosphonates with 5-azacytosine base moiety

Article abstract of DOI:10.1016/j.tet.2019.130529

With respect to the strong antiviral activity of (S)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine various types of its side chain fluorinated analogues were prepared. The title compound, (S)-1-[3-fluoro-2-(phosphonomethoxy)propyl]-5-azacytosine