Synthesis, structural analysis, and SAR studies of triazine derivatives as potent, selective Tie-2 inhibitors

DOI: 10.1016/j.bmcl.2007.02.067

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2886 - 2889 (2007)

Update date:2022-08-04

Topics:

Authors:

Hodous, Brian L.

Geuns-Meyer, Stephanie D.

Hughes, Paul E.

Albrecht, Brian K.

Bellon, Steve

Caenepeel, Sean

Cee, Victor J.

Chaffee, Stuart C.

Emery, Maurice

Fretland, Jenne

Gallant, Paul

Gu, Yan Gu, Yan

Johnson, Rebecca E.

Kim, Joseph L.

Long, Alexander M.

Morrison, Michael

Olivieri, Philip R.

Patel, Vinod F.

Polverino, Anthony

Rose, Paul

Wang, Ling

Zhao, Huilin

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Article abstract of DOI:10.1016/j.bmcl.2007.02.067

A novel class of selective Tie-2 inhibitors was derived from a multi-kinase inhibitor 1. By reversing the amide connectivity and incorporating aminotriazine or aminopyridine hinge-binding moieties, excellent Tie-2 potency and KDR selectivity could be achi

Full text of DOI:10.1016/j.bmcl.2007.02.067

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