Atovaquone derivatives as potent cytotoxic and apoptosis inducing agents

DOI: 10.1016/j.bmcl.2009.07.044

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 5091 - 5094 (2009)

Update date:2022-08-03

Topics:

Authors:

Zhou, Jing

Duan, Lei

Chen, Huaming

Ren, Xiaomei

Zhang, Zhang

Zhou, Fengtao

Liu, Jinsong

Pei, Duanqing

Ding, Ke

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Article abstract of DOI:10.1016/j.bmcl.2009.07.044

2-Piperazinyl naphthoquinones (2) and 2-piperidinyl naphthoquinones (3) were designed and synthesized as new cytotoxic and apoptosis inducing agents by utilizing the anti-parasite drug atovaquone as lead compound. Several compounds displayed significantly

Full text of DOI:10.1016/j.bmcl.2009.07.044

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