Journal of Pharmaceutical Sciences p. 913 - 915 (1990)
Update date:2022-08-03
Topics:
Yu
Portmann
A novel antiasthmatic, 2-[(4-hydroxyphenyl)amino]-5-methoxybenzenemethanol (1), oxidizes to the corresponding iminoquinone in aqueous solutions. The reaction was monitored by a paired-ion reversed-phase HPLC method. The oxidation rate was highly dependent on the solution pH, with a large rate increase occurring above pH 6.1. In nonaqueous solution, the oxidation reaction was significantly slower. Ascorbic acid protects 1 from oxidation. The aqueous solution of the decomposed product is reduced to 1 in the presence of ascorbic acid.
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Doi:10.1021/j100188a058
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(1992)Doi:10.1016/S0040-4039(00)92322-0
(1992)Doi:10.1007/s00706-012-0851-0
(2013)Doi:10.1039/c2cc35309a
(2012)Doi:10.1021/acs.jmedchem.0c00395
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