Solid phase synthesis of 2-aminobutadienes using a piperazine linker

Article abstract of DOI:10.1016/S0040-4039(97)01633-X

A series of resin-bound 4-substituted-2-aminobutadienes have been synthesised via Wittig reaction with polymer supported 2-(N-piperazino)prop-1-enyl-1-triphenylphosphonium bromide. The use of piperazine provides a readily cleavable enamine linker for attachment of ketones that is compatible with anion chemistry.