Journal of Organic Chemistry p. 670 - 673 (1985)
Update date:2022-08-02
Topics:
Royer, Jacques
Husson, Henri-Philippe
The alkylation of the chiral 2-cyano-6-oxazolopiperidine synthon (1) with the iodo ketal 2 gave, after selective cleavage of the cyano group, the oxazolopiperidine 4 having the 2S configuration.Compound 4 was alkylated with CH3MgI, giving a 4:1 mixture of
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