Synthesis of 4-substituted- and 1,4-disubstituted-4-hydroxypyrrolidin-2- ones

DOI: 10.1080/00397910701319023

Source and publish data:

Synthetic Communications p. 1845 - 1852 (2007)

Update date:2022-08-04

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Authors:

Kinsinger, Christopher R.

Tatko, Chad D.

Whelan, Christopher M.

Wilkinson, Timothy J.

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Article abstract of DOI:10.1080/00397910701319023

This report describes the synthesis of 4-substituted- and 1,4-disubstituted-4-hydroxypyrrolidin-2-ones by cyclization of intermediate γ-aminoesters prepared from alkylbenzylamines, α-bromoketones, and lithio ethyl acetate. Copyright Taylor & Francis Group, LLC.

Full text of DOI:10.1080/00397910701319023

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