Journal of Medicinal Chemistry p. 3969 - 3972 (2007)
Update date:2022-07-29
Topics:
Li, Hui
Linton, Angelica
Tatlock, John
Gonzalez, Javier
Borchardt, Allen
Abreo, Mel
Jewell, Tanya
Patel, Leena
Drowns, Matthew
Ludlum, Sarah
Goble, Mike
Yang, Michele
Blazel, Julie
Rahavendran, Ravi
Skor, Heather
Shi, Stephanie
Lewis, Cristina
Fuhrman, Sheila
The discovery and optimization of a novel class of carbon-linked dihydropyrones as allosteric HCV NS5B polymerase inhibitors are presented. Replacement of the sulfur linker atom with carbon reduced compound acidity and greatly increased cell permeation. F
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Doi:10.1039/c39720000887
(1972)Doi:10.1016/j.bmcl.2007.04.046
(2007)Doi:10.1021/jm0706968
(2007)Doi:10.1016/j.tet.2007.05.007
(2007)Doi:10.1021/ja053674o
(2005)Doi:10.1007/BF00528645
(1993)