Synthetic Approach to the Amphilectane Diterpenes: The Use of Nitriles as Terminators of Carbocation-Olefin Cyclizations

Article abstract of DOI:10.1021/jo00205a015

A biomimetic approach to the synthesis of tricyclic terpenoid isonitriles from marine sponges is described which involves carbocation-olefin cyclization of polyolefinic precursors terminated by the stereoselective formation of a carbon-nitrogen bond.The k