Benzothiopyranoindazoles, a new class of chromophore modified anthracenedione anticancer agents. Synthesis and activity against murine leukemias

DOI: 10.1021/jm00403a009

Source and publish data:

Journal of Medicinal Chemistry p. 1527 - 1539 (1988)

Update date:2022-07-29

Topics: Synthesis Anticancer agents Chromophore

Authors:

Hollis Showalter

Angelo Angelo

Berman Berman

Kanter Kanter

Ortwine Ortwine

Ross-Kesten

Sercel Sercel

Turner Turner

Werbel Werbel

Worth Worth

Elslager

Leopold Leopold

Shillis Shillis

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Article abstract of DOI:10.1021/jm00403a009

The synthesis of the benzothiopyranoindazoles (3), a new class of chromophore modified anthracenediones related to mitoxantrone (1), is described. In this structural class the quinone moiety, which is believed to be responsible for the cardiotoxicity of t

Full text of DOI:10.1021/jm00403a009

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