Synthesis of amino sugars through a highly diastereoselective dipolar cycloaddition. Enantioselective synthesis of the carbohydrate segment of Sch 38516

Article abstract of DOI:10.1016/S0040-4020(97)01023-5

A concise and stereoselective route for the synthesis of the carbohydrate moiety of the antifungal agent Sch 38516 is described. The synthesis scheme includes a dipolar cycloaddition, which is rendered diastereoselective through the use of a readily available and easily removable chiral auxiliary.