Carboxyl-Mediated Pictet-Spengler Reaction. Direct Synthesis of 1,2,3,4-Tetrahydro-β-carbolines from Tryptamine-2-carboxylic Acids

DOI: 10.1021/jo00001a066

Source and publish data:

Journal of Organic Chemistry p. 359 - 365 (1991)

Update date:2022-08-03

Topics:

Authors:

Narayanan, Krishnaswamy

Schindler, Liesl

Cook, James M.

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Article abstract of DOI:10.1021/jo00001a066

The Pictet-Spengler condensation of various tryptamine-2-carboxylic acids 9a-f with carbonyl compounds in benzene/dioxane/trifluoroacetic acid (Table I) with simultaneous loss of carbon dioxide afforded directly the corresponding 1,2,3,4-tetrahydro-β-carb

Full text of DOI:10.1021/jo00001a066

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