Synthesis and biological evaluation of 4′-(6,7-disubstituted-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-biphenyl-4-ol as potent Chk1 inhibitors

DOI: 10.1016/j.bmcl.2007.05.027

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 4308 - 4315 (2007)

Update date:2022-08-05

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Authors:

Tao, Zhi-Fu

Li, Gaoquan

Tong, Yunsong

Chen, Zehan

Merta, Philip

Kovar, Peter

Zhang, Haiying

Rosenberg, Saul H.

Sham, Hing L.

Sowin, Thomas J.

Lin, Nan-Horng

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Article abstract of DOI:10.1016/j.bmcl.2007.05.027

A new series of potent tricyclic pyrazole-based Chk1 inhibitors are described. Analogues disubstituted on the 6- and 7-positions show improved Chk1 inhibition potency compared with analogues with a single substituent on either the 6- or 7-position. Based

Full text of DOI:10.1016/j.bmcl.2007.05.027

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