Journal of Medicinal Chemistry p. 6225 - 6236 (2015)
Update date:2022-08-04
Topics:
Priestley, E. Scott
Cheney, Daniel L.
DeLucca, Indawati
Wei, Anzhi
Luettgen, Joseph M.
Rendina, Alan R.
Wong, Pancras C.
Wexler, Ruth R.
On the basis of a crystal structure of a phenylpyrrolidine lead and subsequent molecular modeling results, we designed and synthesized a novel series of macrocyclic FVIIa inhibitors. The optimal 16-membered macrocycle was 60-fold more potent than an acycl
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