
Helvetica Chimica Acta p. 182 - 186 (1998)
Update date:2022-07-29
Topics:
Eberle, Marcel K.
Keese, Reinhart
Stoeckli-Evans, Helen
(-)-(R)-4,4,4,4′,4′,4′-Hexafluorovaline hydrochloride ((R)-5) of 98% ee is prepared from β,β-bis(trifluoromethyl)acrylic acid ( = benzyl 4,4,4-trifluoro-3-(trifloromethyl)but-2-enoate; 1) in 4 steps with an overall yield of 9.6%. Key step is the separatio
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