Tetrahedron p. 15937 - 15958 (1998)
Update date:2022-08-05
Topics:
Liu, Yaoquan
Li, Zhe
Vederas, John C.
Biosynthesis of the polyketide, dehydrocurvularin 1, by Alternaria cinerariae was examined by incorporation experiments with N-acetylcysteamine (NAC) thiolesters of potential labeled di-, tri-, tetra-, and pentaketide assembly intermediates, 5-10. The results show that diketide and α,β- unsaturated tetraketide precursors can be utilized intact, whereas a saturated tetraketide can not, thereby suggesting that 1 is the initial PKS product. Curvularin 2 and 1 could not be interconverted by A. cinerariae, but 8-hydroxycurvularin 3 and 1 are transformed into each other by component(s) in the fermentation media.
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