Synthesis and biological activity of 1α-fluoro-25-hydroxyvitamin D3

DOI: 10.1248/cpb.32.3525

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 3525 - 3531 (1984)

Update date:2022-09-26

Topics:

Authors:

Ohshima Ohshima

Sai Sai

Takatsuto

Ikekawa Ikekawa

Kobayashi

Tanaka Tanaka

DeLuca DeLuca

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Article abstract of DOI:10.1248/cpb.32.3525

trans Diaxial opening with potassium hydrogen difluoride of the 1β,2β-epoxy-3β-ol derived from cholenic acid gave the 1α-fluoro-2β,3β-diol derivative. Construction of the 25-hydroxy cholesterol side chain and deoxygenation of the 2β-hydroxy group afforded

Full text of DOI:10.1248/cpb.32.3525

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Product name:1α-fluoro-25-hydroxyvitamin D3 3-acetate

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