Bioorganic and Medicinal Chemistry Letters p. 400 - 405 (2007)
Update date:2022-08-04
Topics:
Garzya, Vincenzo
Forbes, Ian T.
Gribble, Andrew D.
Hadley, Mike S.
Lightfoot, Andrew P.
Payne, Andrew H.
Smith, Alexander B.
Douglas, Sara E.
Cooper, David G.
Stansfield, Ian G.
Meeson, Malcom
Dodds, Emma E.
Jones, Declan N.C.
Wood, Martyn
Reavill, Charlie
Scorer, Carol A.
Worby, Angela
Riley, Graham
Eddershaw, Peter
Ioannou, Chris
Donati, Daniele
Hagan, Jim J.
Ratti, Emiliangelo A.
A rational structure-activity relationship study around compound (1) is reported. The lead optimisation programme led to the identification of sulfonamide (25), a molecule combining dopamine D2/D3 receptor antagonism with serotonin 5
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