HIGH STEREOSELECTIVE SYNTHESIS OF DIETHYL (2,3-ISOPROPYLIDENE-5-TRITYL-α-D-RIBOFURANOSYL)-METHANEPHOSPHONATE, A PRECURSOR TO THE PHOSPHONO ANALOG OF α-D-RIBOSE 1-PHOSPHATE

Article abstract of DOI:10.1016/S0040-4039(01)81725-1

The reaction of 2,3-isopropylidene-5-trityl-D-ribofuranose with methylenetriphenylphosphorane and the subsequent mercuriocyclization, iodomercuriation and Arbuzov reaction, allow a highly stereoselective entry to the phosphono analog of α-D-ribose 1-phosp