Bioorganic and Medicinal Chemistry Letters p. 869 - 874 (1999)
Update date:2022-07-30
Topics: Synthesis In vitro Mass spectrometry Derivatives High-performance liquid chromatography (HPLC) in vivo Pharmacokinetics Bioavailability Insulin Sensitivity Glucose tolerance test Hypoglycemic effect
Shin, Joon-Su
Kim, Kyoung-Soon
Kim, Myoung-Bohm
Jeong, Jae-Hoon
Kim, Bak-Kwang
A series of 18 chrysin derivatives, prepared by alkylation and condensation, were fully characterized by NMR and other techniques and tested in vivo against the diabetes mellitus. Several modified compounds especially those with propyl, butyl, octyl and tolyl groups were found to have hypoglycemic effect on diabetic mice in spite of the fact that chrysin itself had inhibited insulin release by 40-60%. None of the test animals died at the maximum dose 500mg/kg and did not cause any significant change in general feature, water and food consumption, body weight and organ weight when we examined the acute oral toxicity of those compounds having significant hypoglycemic effect.
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