Bis-azaaromatic quaternary ammonium salts as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release: An investigation of binding conformation

DOI: 10.1016/j.bmcl.2007.10.052

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 6734 - 6738 (2007)

Update date:2022-07-29

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Authors:

Zheng, Guangrong

Zhang, Zhenfa

Pivavarchyk, Marharyta

Deaciuc, Agripina G.

Dwoskin, Linda P.

Crooks, Peter A.

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Article abstract of DOI:10.1016/j.bmcl.2007.10.052

A series of conformationally restricted bis-azaaromatic quaternary ammonium salts (3 and 4) have been designed and synthesized in order to investigate the possible binding conformations of N,N′-dodecane-1,12-diyl-bis-3-picolinium dibromide (bPiDDB; 2), a

Full text of DOI:10.1016/j.bmcl.2007.10.052

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