Structure-activity relationship in PAF-acether. 2. rac-1-O-octadecyl-2-O-acetyl-3-O-[γ-(dimethylamino)propyl]glycerol

Article abstract of DOI:10.1021/jm00146a019

Two products without phosphoryl groups, 1-O-octadecyl-2-O-acetyl-3-O-[γ-(dimethylamino)propyl]glycerol and its quaternary salt, were synthesized from 1-O-octadecyl-2-O-benzylglycerol. In comparison with PAF-acether, they lost aggregating and bronchoconstr