2-[(arylmethyl)amino]-2-methyl-1,3-propanediol DNA intercalators. An examination of the effects of aromatic ring variation on antitumor activity and DNA binding

DOI: 10.1021/jm00111a010

Source and publish data:

Journal of Medicinal Chemistry p. 1983 - 1990 (1991)

Update date:2022-07-30

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Authors:

Bair Bair

Andrews Andrews

Tuttle Tuttle

Knick Knick

Cory Cory

McKee McKee

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Article abstract of DOI:10.1021/jm00111a010

The effects of variation of aromatic ring size, shape, and side-chain position on antitumor activity and DNA binding in a series of carbocyclic 2-[(arylmethyl)amino]-2-methyl-1,3-propanediols (AMAPs) were examined. In general, the interaction of AMAPs wit

Full text of DOI:10.1021/jm00111a010

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