Stereocontrolled total synthesis of the chiral building block (3S,4R)-3-[(R)-1-hydroxyethyl]-4-acetyloxy-azetidin-2-one: A useful synthon for the synthesis of (+)-thienamycin, carbapenems and penems

Article abstract of DOI:10.1016/S0040-4039(00)61969-X

A total stereocontrolled synthesis of (1), an intermediate in the synthesis of (+)-thienamycin, carbapenems and penems, based on a strategy that uses the S(-)hydroxyethylbutyrate as chiral building block, is reported.