Stereoselective synthesis of both enantiomers of P-chirogenic 2-oxo-2-thio-1,3,2-oxazaphosphorinane tetramethylammonium salt as key precursors to structurally diverse chiral derivatives

Article abstract of DOI:10.1016/j.tet.2011.10.085

A fully stereoselective synthesis of both enantiomers of 2-oxo-2-thio-1,3,2-oxazaphosphorinanyl salt has been accomplished in five steps with an overall 40-45% yield starting from the diastereoisomeric N-methylstrychninium salts of methyl p-nitrophenyl ph