Synthesis and biological activity of carboxylic acid replacement analogues of the potent angiotensin converting enzyme inhibitor 5(S)-benzamido-4-oxo-6-phenylhexanoyl-L-proline

Article abstract of DOI:10.1021/jm00146a015

The carboxylic acid group on the proline of the ketomethylene analog of the tripeptide Bz-Phe-Gly-Pro 1 was replaced by a phosphoric acid, a hydroxamic acid, and a tetrazole to give compounds 2-4, respectively. Testing of 2-4 as angiotensin converting enz