40
Med Chem Res (2008) 17:30–41
Andreani A, Granaiola M, Guardigli M, Leoni A, Locatelli A, Morigi R, Rambaldi M, Roda A (2005b)
Synthesis and chemiluminescent high throughput screening for inhibition of acetylcholinesterase
activity by imidazo[2,1-b]thiazole derivatives. Eur J Med Chem 40:1331–1334
Athen B, Guglielmi H (1969) Metabolic properties of tumor slices under the influence of cytostatic
compounds. Hoppe-Seyler’s Z Physiol Chem 350:803–808. (C.A., 71, 59266k)
Auerbach SS, Stoner MA, Su SZ, Omiecinski C (2005) Retinoid X receptor-alpha-dependent
transactivation by a naturally occurring structural variant of human constitutive androstane receptor
(NR1I3). J Mol Pharmacol 68:1239–1253
Bagrii AK, Galenko GF, Kochergin PM (1975) Synthesis of [1,3]thiazino[3,2-a]imidazole and its
condensed analogs. Dopovidi Akademii Nauk Ukrains’koi RSR, Seriya B: Geologiya Geofizika
Khimiya ta Biologiya 9:801–804
Bender PE (1978) 2,3-Dihydroimidazo[2,1-b]thiazoles. DE Patent 2742725 issued on March 30, 1978
Bender PE (1981) 5,6-Diphenyl-2,3-dihydroimidazo[2,1-b]thiazoles. US Patent 4263311 issued on April
21, 1981
Bender PE, Gleason JG, Griswold DE, Hanna N, Lantos I, Razgaitis KA, Sarau HM, Shilcrat SC (1992)
Inhibition of the 5-lipoxygenase pathway. US Patent 5134150 issued on July 28, 1992
Bender PE, Hill D, Offen PH, Razgaitis K, Lavanchy P, Stringer OD, Sutton BM, Griswold DE,
DiMartino M, Walz DT, Lantos I, Ladd CB (1985) 5,6-Diaryl-2,3-dihydroimidazo[2,1-b]thiazoles: a
new class of immunoregulatory antiinflammatory agents. J Med Chem 28:1169–1177
Broom NJP, Harrington FP (2003) 6-(substituted methylene) penems and intermediates. US Patent
6600035 (B1) issued on July 29, 2003
¨
Cesur Z, Gu¨ner H, Otu¨k G (1994) Synthesis and antimycobacterial activity of new imidazo[2,1-b]thiazole
derivatives. Eur J Med Chem 29:981–983
Cheng HY, Davis LL, Bender PE, Gleason J (1989) Electrochemical investigations of anti-inflammatory
agents 5,6-substituted-2,3-dihydroimidazo[2,1-b]thiazoles. J Electrochem Soc 136: 3679–3683
Cherkofsky SC, Sharpe TR (1977) Antiinflammatory diarylimidazothiazoles and their corresponding
S-oxides. US Patent 4064260 – issued on Dec 20, 1977
C¸ apan G, Ulusoy N, Ergenc¸ N, Kiraz M (1999) New 6-phenylimidazo[2,1-b]thiazole derivatives:
Synthesis and antifungal activity. Monatsh Chem 130:1399–1407
Dou HJM, Ludwikow M, Hassanaly P, Kister J, Metzger J (1980) Synthesis of heterocycles by phase-
transfer catalysis. J Het Chem 17:393–395
Fatimi J, Lagorce JF, Chabernaud ML, Comby F, Buxeraud J, Raby C (1993) Structure-activity relations
of 1,4,5-trialkyl-2-thioimidazole towards the biological activity of thyroperoxidase. Bull Soc Pharm
Bordeaux 132:53–64 (C.A., 121, 169756d)
Feil VJ, (1996) Synthesis of C-14-Labeled levamisole and C-13-labeled tetramisole. J Labelled Compd
Radiopharm 38:1071–1076
Gadad AK, Mahajanshetti CS, Nimbalkar S, Raichurkar A (2000) Synthesis and antibacterial activity of
some 5-guanylhydrazone/thiocyanato-6-arylimidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide deriva-
tives. Eur J Med Chem 35:853–857
Garbisa S, Pozzatti R, Muschel RJ, Saffiotti U, Ballin M, Goldfarb RH, Khoury G, Liotta LA (1987)
Secretion of type IV collogenolytic protease and metastatic phenotype: Induction by transfection
with c-HA-ras but not c-Ha-ras plus Ad2-Ela. Cancer Res 47:1523–1528
Goeschke R, Ferrini PG (1980) Bicyclic thiadiaza compounds and their use as medicaments. GB Patent
2039882 issued on August 20, 1980
Gregoire J, Girard P, Barbaud J (1951) Sun-ray protective substances. I. 4,5-Diphenyl-2(3H)-
imidazolone, di-Na salt of 4,5-bis(p-sulfophenyl)-2(3H)-imidazolone, 4,5-diphenyl-2-mercaptoim-
idazole, and isobutyl p-dimethylamino benzoate. Ann Pharm Franc¸ 9:493–513 (C.A., 46, 2752i)
Guglielmi H (1968) Cytostatic thymine derivatives of imidazole-2-thione. Z Physiol Chem 349:1733–
1738 (C.A., 70, 68301z)
Gupta RP, Pujari HK (1978) Heterocyclic systems containing a bridgehead nitrogen atom: Part XXX.
Reaction of 2-mercapto-4,5-dianisylimidazole with chloroacetic acid and alkyl halides. Indian J
Chem Sect B 16B:329–331
Gu¨rsoy E, Ulusoy-Gu¨zeldemirci N (2007) Synthesis and primary cytotoxicity evaluation of new
imidazo[2,1-b]thiazole derivatives. Eur J Med Chem 42:320–326
Ide WS, Buck JS (1948). In ‘‘Organic Reactions’’; R. Adams, Ed.; Wiley: NewYork, NY; Chapter 5
Jiang B, Liu Y, Bao M, An LJ (2003) Hydrogen peroxide-induced apoptosis in pc12 cells and the
protective effect of puerarin. Cell Biol Int 27:1025–1031