A Practical Stereospecific Synthesis of the Biotin Precursor (3aα,6aα)-1,3-Dibenzylhexahydro-1H-thienoimidazol-2(3H)-one 1,1-Dioxide

DOI: 10.1039/c39850000353

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 353 - 354 (1985)

Update date:2022-07-30

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Authors:

Bates, Hans Aaron

Smilowitz, Lloyd

Rosenblum, Stuart B.

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Article abstract of DOI:10.1039/c39850000353

A highly efficient stereospecific synthesis of the biotin precursor (3aα,6aα)-1,3-dibenzylhexahydro-1H-thieno<3,4-d>imidazol-2(3H)-one 1,1-dioxide (6) is reported, by the cyclisation of the urea (5), which was obtained from the amine (4), (4) itself being prepared by the reaction of the dibromide (2) with benzylamine.

Full text of DOI:10.1039/c39850000353

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Product name:1,3-Dibenzyl-1-(1,1-dioxo-2,3-dihydro-1H-1λ⁶-thiophen-3-yl)-urea

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