Journal of Medicinal Chemistry p. 112 - 125 (1986)
Update date:2022-08-03
Topics:
Stuetz, Anton
Georgopoulos, Apostolos
Granitzer, Waltraud
Petranyi, Gabor
Berney, Daniel
Naftifine (1) is the first representative of the new antifungal allylamine derivatives.Its biological activity is strictly bound to specific structural requirements that are unrelated to those of known antifungals.A tertiary allylamine function seems to be a prerequisite for activity against fungi.By systematic variation of the individual structural elements in 1, detailed structure-activity relationships are defined in which the phenyl ring is the structural feature permitting the widest variations.Versatile synthetic routes to allylamine derivatives and comparative biological data are presented.
View MoreContact:0086-22-2822 1962 / 2822 1963
Address:B-808, No. 1, North-South Street, Hexi District,
Nanjing HuiBaiShi Biotechnology Co.,Ltd.
Contact:+86 (25)58745219
Address:No.606 Ningliu Road,LiuHe District.
Shanghai Haoyuan Chemexpress Co., Ltd.
website:https://www.chemexpress.com/
Contact:86-21-58950125
Address:No.3 Building, No.1999, Zhangheng Road, ZhangjiangHighTech Park, Shanghai, P.R.China,201203
ALPHA PHARMACEUTICAL CO，LTD JIANGSU
Contact:+86-527-84829968,+86-527-84829998
Address:suqian city
Hebei Think-Do Environment Co., Ltd
website:http://www.thinkdo-environment.com
Contact:0311-86510809-
Address:No 6, Shilian Middle Street, Circular Chemical Industry Park
Doi:10.1039/a803229g
(1998)Doi:10.1016/S0022-328X(98)00835-3
(1998)Doi:10.1021/ja9721632
(1998)Doi:10.1016/S0022-328X(00)81471-0
(1981)Doi:10.1248/cpb.44.1603
(1996)Doi:10.1016/S0040-4039(98)01524-X
(1998)
