Journal of Medicinal Chemistry p. 112 - 125 (1986)
Update date:2022-08-03
Topics:
Stuetz, Anton
Georgopoulos, Apostolos
Granitzer, Waltraud
Petranyi, Gabor
Berney, Daniel
Naftifine (1) is the first representative of the new antifungal allylamine derivatives.Its biological activity is strictly bound to specific structural requirements that are unrelated to those of known antifungals.A tertiary allylamine function seems to be a prerequisite for activity against fungi.By systematic variation of the individual structural elements in 1, detailed structure-activity relationships are defined in which the phenyl ring is the structural feature permitting the widest variations.Versatile synthetic routes to allylamine derivatives and comparative biological data are presented.
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