Chemical and Pharmaceutical Bulletin p. 1603 - 1606 (1996)
Update date:2022-08-03
Topics:
Morita, Makoto
Nakanishi, Hiroshi
Morita, Hiroshi
Mihashi, Susumu
Itokawa, Hideji
Sesquiterpenes isolated from Alpinia speciosa and Alpinia japonica, and their derivatives were found to inhibit histamine- or barium chloride- induced contraction of excised guinea pig ileum when tested by the Magnus method. Major spasmolytic principles contained in those extracts were the sesquiterpenes, β-eudesmol, nerolidol, humulene epoxide II and 4α- hydroxydihydroagarofuran. Relationships between the chemical structures of the sesquiterpenes and their derivatives, and their spasmolytic activities were discussed.
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