ENANTIOSPECIFIC TOTAL SYNTHESIS OF (-)-MEGAPHONE BY A HIGHLY CONTROLLED CONSECUTIVE 1,4- AND 1,3-ASYMMETRIC INDUCTION.

Article abstract of DOI:10.1016/S0040-4039(00)61960-3

Enantiospecific total synthesis of (-)-megaphone (1) is reported.The key synthetic tactic is the use of (4S)-2Z-ethylidene-4-trityloxymethyl-butan-4-olide (6) to both establish the relative and absolute stereochemistry of the contiguous tertiary and quate