Enantioselective Preparation of Polyfunctional Secondary Allylic Alcohols Using Functionalized Dialkylzincs Prepared by a Copper(I) Catalyzed Iodine-Zinc Exchange Reaction.

Article abstract of DOI:10.1016/S0040-4039(00)93393-8

Catalytic amounts of Cu(I) salts considerably facilitate the iodine-zinc exchange reaction leading to polyfunctional dialkylzincs.The catalytic asymmetric addition of these zinc reagents to a wide range of α,β-unsaturated aldehydes provides polyfunctional allylic alcohols with a high enantioselectivity.