Direct Acting, Highly Mutagenic, α-Hydroxy N-Nitrosamines from 4-Chloroindoles

DOI: 10.1021/ja00274a043

Source and publish data:

Journal of the American Chemical Society p. 4115 - 4119 (1986)

Update date:2022-08-03

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Authors:

Buechi, George

Lee, Gary C. M.

Yang, David

Tannenbaum, Steven R.

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Article abstract of DOI:10.1021/ja00274a043

Fave beans (Vicia fava) contain 4-chloro-6-methoxyindole, a promutagen, which on nitrosation under simulated gastric conditions forms 4-chloro-6-methoxy-2-hydroxy-N₁-nitrosoindolin-3-one oxime, a direct-acting, exceedingdly potent, mutagen whic

Full text of DOI:10.1021/ja00274a043

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