Bioorganic and Medicinal Chemistry Letters p. 5619 - 5623 (2013)
Update date:2022-08-17
Topics:
Trush, Viacheslav V.
Cherenok, Sergiy O.
Tanchuk, Vsevolod Yu.
Kukhar, Valery P.
Kalchenko, Vitaly I.
Vovk, Andriy I.
Calix[4]arenes bearing methylenebisphosphonic or hydroxymethylenebisphosphonic acid fragments at the wide rim of the macrocycle were studied as inhibitors of PTP1B. Some of the inhibitors showed IC 50 values in the micromolar range and good sel
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