European Journal of Medicinal Chemistry p. 331 - 334 (1996)
Update date:2022-08-17
Topics:
Musso
Boswell
Mehta
Soroko
Burchall
A series of benzamides containing N,N,2-trimethyl-1,2-propane diamine as the amide moiety was synthesized. The compounds were evaluated in the maximal electroshock (MES) and pentylenetetrazol (metrazole, MET) screens for anticonvulsant activity. The 3,5-trifluoromethyl, 3,5-dichloro, and 3-bromo analogues proved to be either equipotent with or more potent than phenytoin.
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