Tetrahedron Letters p. 8331 - 8334 (1997)
Update date:2022-08-25
Topics:
Cho, Yoon Hwan
Park, Jae Chan
A very convenient dimethylamination of activated aromatic halides was achieved by using N,N-dimethylformamide(DMF) and ethanolamines. p- Nitrochlorobenzene, 2-halopyridines, 2-chloroquinoline and 2-chloropyrimidine gave the corresponding dimethylamino substituted products when treated with DMF and diethanolamine in 80-92% yield.
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