Release kinetics of nicotinamide from fatty acid-nicotinamide equimolar complexes. I. Release characteristics of fatty acid complexes

Article abstract of DOI:10.1248/cpb.39.2696

The rates of release of nicotinamide (NAA) from fatty acid (FA)-NAA complexes, FA-NAA, were determined in a JP XI dissolution test apparatus in 500 ml of JP XI disintegration test medium No. 1 at 37°C. The release rate constant (k) and the activation Gibbs energy (ΔG⁺) for the release of NAA from FA-NAA were estimated. The results obtained for FA-NAA were compared with previous results obtained for the thiamine disulfide (TDS) complex, (FA)₆-(TDS). The plots of log k against the carbon number of the constituent FA (n) presented a zig-zag line which indicates a downward convex at an odd-numbered position. The plots of ΔG⁺ against n showed a zig-zag line with an upward convex at an odd-numbered position, though the positive value of ΔG± increased rather regularly with an increase of n for either even-numbered or odd-numbered FA. The phenomena that the plots of log k vs. n and ΔG⁺ vs. n show zig-zag lines due to the difference between even- and odd-numbered FA were the same as observed previously for the release of TDS from (FA)₆ (TDS).

Full text of DOI:10.1248/cpb.39.2696

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