Trimethylamine N-oxide: A novel reagent for the promotion of the retro- aldol reaction of R106-1 (LY295337)

DOI: 10.1016/0040-4039(96)00830-1

Source and publish data:

Tetrahedron Letters p. 4301 - 4304 (1996)

Update date:2022-08-11

Topics:

Authors:

Rodriguez

Zweifel Zweifel

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0040-4039(96)00830-1

The retro-aldol reaction of R106-1 (LY295337), 1 using trimethylamine N- oxide (TNO) facilitates the removal of the tertiary hydroxy group generating R106-sarcosine, 2 a key synthetic intermediate. The reagent is highly reproducible and provides high yields with no major side products. A side by side comparison of TNO vs. traditional bases is described.

Full text of DOI:10.1016/0040-4039(96)00830-1

Products guided by the article

Product name:Ethyl phenylacetate

Cas No:101-97-3

R&D Labs maybe for 101-97-3

Fuxin Jintelai Fluorin Chemical Co., Ltd.

Contact:+86-0418-8229599

Address:, 7th Huagong Road, Fluorine industry development zone (Yimatu Town,Fumeng County),Fuxin City, Liaoning Province, China
Shanghai Maxchemco Chemical Industry Co., Ltd.

Contact:(86)21-51079223

Address:No.1305-8, B241, the Ecust Park, Huajing Road, Xuhui District, Shanghai
Hangzhou yi lu biont technology Co., LTD

Contact:+86-571-88152630

Address:Hangzhoushi HuafengRoad Yicheng3Building1001room.
Chengdu Biopurify Phytochemicals Ltd.

website:http://www.phytopurify.com

Contact:+86-28-82633397

Address:2F,No.11 Building,No.388 Rongtaidadao CNSTP,Wenjiang Zone,Chengdu,Sichuan, China
SHIJIAZHUANG AGERUO-BIOTECH CO.LTD

Contact:+86-130-2866-6699

Address:Huaian east Road 158

Relevant to this article

Mercury in Organic Chemistry. 28. Synthesis of (?-Allyl)palladium Compounds by Remote Palladium Migration

Doi:10.1021/jo00189a009
(1984)
CH STRETCHING FREQUENCES AND BOND STRENGTHS, AND METHYL GROUP GEOMETRY IN CH3CXO COMPOUNDS ( X = H, Me, F, Cl, Br, I, CN, OMe) AND CH3CH2CN

Doi:10.1016/0022-2860(82)80078-1
(1982)
A Formal [3 + 2] Alkene Addition to Benzhydrol Cations. A Practical and Mild Methodology for the Synthesis of Substituted 1-Arylindanes and Related Compounds

Doi:10.1081/SCC-120027710
(2004)
Mechanistic study of decomposition of cyclohexyl hydroperoxide catalysed by manganese(III) tetraarylporphyrins

Doi:10.1002/recl.19931120903
(1993)
Synthesis and characterization of banana-shaped mesogens derived from a benzophenone moiety

Doi:10.1080/15421400903291392
(2009)
ALKYLATION OF PHENOLS BY METHANOL WITHOUT CATALYST

Doi:10.1007/BF00953961
(1985)

Article Doi