Tetrahedron Letters p. 4301 - 4304 (1996)
Update date:2022-08-11
Topics:
Rodriguez
Zweifel
The retro-aldol reaction of R106-1 (LY295337), 1 using trimethylamine N- oxide (TNO) facilitates the removal of the tertiary hydroxy group generating R106-sarcosine, 2 a key synthetic intermediate. The reagent is highly reproducible and provides high yields with no major side products. A side by side comparison of TNO vs. traditional bases is described.
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