Synthesis of GABA-valproic acid derivatives and evaluation of their anticonvulsant and antioxidant activity

Article abstract of DOI:10.1002/ardp.19963290804

The synthesis and the anticonvulsant activity of a number of GABA and valproic acid derivatives are reported. The lipophilicity of these compunds and their inhibitory effect on lipid peroxidation were also investigated, in an effort to correlate the anticonvulsant activity with lipophilicity and inhibitory effect on lipid peroxidation. The synthetized compounds exhibited anticonvulsant effects which were stronger for the more lipophilic derivatives. One of the active anticonvulsants showed appreciable antioxidant properties. Finally, a good correlation was found between the experimentally derived (R(M)) and calculated (Σf and log P(SK)) lipophilicity for this series of compounds.