New δ-aminoalcohol for the enantioselective addition of dialkylzincs to aldehydes

Article abstract of DOI:10.1016/S0957-4166(97)00534-X

A new optically active δ-aminoalcohol has been synthesized diastereoselectively in one step from (-)-menthone and N,N-dimethylaminopropyl lithium. The aminoalcohol catalyzed the addition of diethylzinc and dimethylzinc to aldehydes in high yields and enantioselectivities of up to 89%.