
Tetrahedron Letters p. 8081 - 8084 (1996)
Update date:2022-08-17
Topics:
Mayer, John P.
Zhang, Jingwen
Bjergarde, Kirsten
Lenz, Doug M.
Gaudino, John J.
1,4-benzodiazepine-2,5-diones were synthesized by a simple procedure utilizing polymer supported amino acids and o-nitrobenzoic acids or protected anthranilic acids. Cyclization of the common aminoamide intermediate with concomitant release from the support furnished the desired 1,4-benzodiazepine-2,5-diones. The products were recovered in high yields and exhibited excellent purities.
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